research and publications
What effect does VasoDrive-AP® have on Stage 1 and 2, ambulatory-monitored hypertensive patients?
The Journal of Clinical Hypertension
Germino FW, Neutel J, Nonaka M, Hendler SS. The impact of lactotripeptides on blood pressure response in stage 1 and stage 2 hypertensives. J Clin Hypertens (Greenwich). 2010;12(3):153-9..
How does level of salt intake affect the antihypertensive effect of lactotripeptides?
Clinical and Experimental Hypertension
Yamasue K, Morikawa N, Mizushima S, Tochikubo O. The blood pressure lowering effect of lactotripeptides and salt intake in 24-h ambulatory blood pressure measurements. Clin Exp Hypertens. 2010;32(4):214-20.
What are the effects of casein hydrolysate containing milk-derived tripeptides val-pro pro (VPP) and ilepro-pro (IPP) on central blood pressure and arterial stiffness?
Atherosclerosis
Nakamura T, Mizutani J, Ohki K, et al. Casein hydrolysate containing Val-Pro-Pro and Ile Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: a randomized, double-blind, placebo-controlled trial. Atherosclerosis. 2011;219(1):298-303.
What is the effect of an excess dosage for evaluating safety of a casein hydrolysate product containing valpro- pro and ile-pro-pro in subjects with normal blood pressure or mild hypertension?
Bioscience, Biotechnology, and Biochemistry
Ishida Y, Shibata Y, Fukuhara I, Yano Y, Takehara I, Kaneko K. Effect of an excess intake of casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro in subjects with normal blood pressure, high-normal blood pressure, or mild hypertension. Biosci Biotechnol Biochem. 2011;75(3):427-33.
What role do val-pro-pro and ile-pro-pro play in patients with Stage 1 hypertension and in nondipper patients (those who do not have low dips in blood pressure at different times)?
Journal of Medicinal Food
Kurosawa MT, Nakamura Y, Yamamoto N, Yamada K, Iketani T. Effects of Val-Pro-Pro and Ile Pro-Pro on nondipper patients: a preliminary study. J Med Food. 2011;14(5):538-42.
What is the beneficial effect of actotripeptides on arterial compliance in postmenopausal women?
American Journal of Physiology: Heart and Circulatory Physiology
Yoshizawa M, Maeda S, Miyaki A, et al. Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women. Am J Physiol Heart Circ Physiol. 2009;297(5):H1899-903.
What additive effects are there of lactotripeptides intake with regular exercise on endothelium-dependent dilatation in postmenopausal women?
American Journal of Hypertension
Yoshizawa M, Maeda S, Miyaki A, et al. Additive beneficial effects of lactotripeptides intake with regular exercise on endothelium dependent dilatation in postmenopausal women. Am J Hypertens. 2010;23(4):368-72.
Do the antihypertensive tripeptides val-pro pro and ile-pro-pro improve vascular endothelial function independent of blood pressure lowering effects?
Hypertension Research
Hirota T, Ohki K, Kawagishi R, et al. Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin converting enzyme. Hypertens Res. 2007;30(6):489-96.
What effect do lactotripeptides have on 24 hour ambulatory blood pressure, blood pressure stress response, pulse wave velocity, and cardiac output in patients with high-normal blood pressure or first degree hypertension?
Hypertension Research
Cicero AF, Rosticci M, Gerocarni B, et al. Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial. Hypertens Res. 2011;34(9):1035-40.
Does fermented milk improve glucose metabolism in exercise-induced muscle damage in healthy young men?
Nutrition Journal
Iwasa M, Aoi W, Mune K, et al. Fermented milk improves glucose
metabolism in exercise-induced muscle damage in young healthy men. Nutr J. 2013;12:83.
What effect does milk casein hydrolysate have in lowering heart rate during downhill walking exercise and reducing muscle damage afterward in middle-aged to elderly men, compared with placebo?
12th Asian Congress of Nutrition
Miyazaki H, Nakamura T, Ohki K, et al. Milk casein hydrolysate lowered heart rate during downhill walking exercise and muscle damage after that in middle aged to elderly men, compared with those of placebo. Poster presented at: 12th Asian Congress of Nutrition; May 2015; Yokohama, Japan.
What is the potential of the proprietary casein hydrolysate on muscle soreness and muscle fatigue in middle-aged to elderly men?
12th Asian Congress of Nutrition14–18, 2015
Iwasa M, Aoi W, Nakayama A, et al. Milk casein hydrolysate alleviates muscle soreness and muscle fatigue after downhill walking exercise in middle aged to elderly men. Poster presented at: 12th Asian Congress of Nutrition; May 2015; Yokohama, Japan.
